Outline of ProMED-mail posts

Isle of Man マン島 (人口 約 82 000人)
「グレートブリテン島とアイルランドに囲まれたアイリッシュ海の中央に位置する島。自治権を持ったイギリスの王室属領。首都 Douglas ダグラス(人口 26 218 人) Wikipedia」
URL “http://ja.wikipedia.org/wiki/マン島”
Strang 村 (ダグラスから ちょっとはずれたところ)
島唯一の総合病院 1施設がある。
URL http://en.wikipedia.org/wiki/Strang,_Isle_of_Man

ProMED-mail Archive Number 20101226.4550
Published Date 26-DEC-2010
Subject PRO/EDR> Staph. aureus (MRSA), USA300 – Isle of Man
Date: Thu 23 Dec 2010
Source: BBC.co.uk [edited]
URL http://www.bbc.co.uk/news/world-europe-isle-of-man-12072292

最近、マン島内で MRSA USA300 に感染した少数の患者が確認された(保健省発表)。
A new strain of the super bug MRSA has been found in the Isle of Man, the Department of Health (DoH) has confirmed. The DoH said it had recently detected a small number of cases of a bacterium called MRSA USA 300.
…

[Mod. ML氏解説:
(命名) USA300 とは S. aureus 黄色ブドウ球菌 "米国"タイプの 1つ。
methicillin-resistant Staphylococcus aureus メチシリン耐性黄色ブドウ球菌 MRSA およびメチシリン感受性黄色ブドウ球菌 の両方に対して、pulsed-field gel electrophoresis パルスフィールドゲル電気泳動 (PFGE)に基づいて 米国 CDCが制定した黄色ブドウ球菌分類体系。

他に、黄色ブドウ球菌分離株の特性を示すために使用される分類
Multilocus sequence typing (MLST [遺伝子配列に基づく分類]), staphylococcus protein A (spa) typing [ブドウ球菌プロテインA に基づく分類] and staphylococcal cassette chromosome mec (SSC mec) typing [ブドウ球菌クロモゾームカセット mec 型に基づく分類] are also used to characterize S. aureus isolates. (SCC mec determines methicillin-resistance. [ブドウ球菌 SSC mec 型はメチシリン耐性を決定する])

たとえば、USA100 は通常、health care-acquired infection 院内感染に関係する MRSA[HA-MRSA] の多剤耐性株である。

過去10年間で、USA300 は 米国内の community-associated 市中感染に関係する MRSA [CA-MRSA]の優位型となった。

It usually carries the genes encoding the Panton-Valentine leucocidin, and is characterized by having the arginine catabolic mobile element (ACME), MLST ST8, spa-sequence type t008, the msr(A) erythromycin resistance gene and SCC mec type IVa. It has caused outbreaks of skin and soft issue infection, as well as invasive disease (e.g., bacteremia, endocarditis, necrotizing pneumonia, and osteomyelitis) in children in daycare centers, military recruits, athletes, prison inmates, and men who have sex with men, in which the infected, but otherwise healthy, individuals had no link to health care systems (1).

USA300 genotype has also emerged as a significant cause of health care-associated infections in some medical facilities (3,4). USA300 isolates are becoming more resistant to antimicrobial agents, including clindamycin, fluoroquinolones, mupirocin and tetracycline, and have spread to Europe, Japan, South America and Australia (1).

Isolation of USA300 in regions outside the U.S. (5-7) has been attributed to importation from the United States due to international travel, with the potential for subsequent spread in the local communities. In the UK, USA300 is still considered uncommon (8).

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