[出 典]
Proc Natl Acad Sci USA. 2010 Aug 17;107(33):14757-62. Epub 2010 Aug 9;
Evidence of intense ongoing endemic transmission of hepatitis C virus in Egypt
http://www.pnas.org/content/early/2010/07/26/1008877107.short?rss=1
By Miller FD, Abu-Raddad LJ.
Abstract
エジプトの C型肝炎ウイルス HCV抗体保有率は世界最高 14.7% (全国, 推定)。慢性感染は推定 9.8%。エジプトの人口の年齢構造の予測から、HCV 新規感染者は毎年 500 000人超と推計。医原性による感染が多い。
ProMED-mail Archive Number 20101109.4070
Published Date 09-NOV-2010
Subject PRO/EDR> Hepatitis C – Egypt
Date: Mon 8 Nov 2010
From Los Angeles Times [edited]
http://latimesblogs.latimes.com/babylonbeyond/2010/11/egypt-hepatitis-c-infection-reaches-alarming-figures.html
[上記の出典より]
HCV 感染率増加の背後にある問題の多くは、医療の監視[体制]不足、誤った医療の衛生[対策]。
“Nearly 7 out of every 1000 Egyptians acquire HCV infections every year. This is the highest level of HCV transmission ever recorded at a national level for a disease transmitted by use of non-sterile medical instruments,” says Dr F DeWolfe Miller, lead author of the study.
Prevalence of hepatitis C in Egypt dates back to the 1970s.
水媒介疾患 bilharzia ビルハルツ住血吸虫症の拡大防止のために、Nile Delta ナイル川デルタ地帯および Upper Egypt [ナイル川上流のエジプト, 南エジプト]の保健当局は tartar emetic 酒石酸アンチモニルカリウム(吐酒石)を駆虫薬として、患者に注射した。注射針の大半は未滅菌であったので、数千人が HCVに感染した (1970年代)。
…
[Mod. CP氏解説:
At least 11 different genotypes of hepatitis C virus have been differentiated which tend to be geographically restricted in their prevalence. Hepatitis C virus genotype 4 has predominated in Egypt.
Unfortunately patients infected with hepatitis C virus genotype 4 tend to respond poorly to interferon alpha [HCV遺伝子型 4 はインターフェロンαにほとんど反応しない], one of the most effective treatment options available for control of HCV infection.
]